Toxin-Antitoxin Systems of Staphylococcus aureus
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چکیده
منابع مشابه
Toxin-Antitoxin Systems of Staphylococcus aureus.
Toxin-antitoxin (TA) systems are small genetic elements found in the majority of prokaryotes. They encode toxin proteins that interfere with vital cellular functions and are counteracted by antitoxins. Dependent on the chemical nature of the antitoxins (protein or RNA) and how they control the activity of the toxin, TA systems are currently divided into six different types. Genes comprising the...
متن کاملProteolytic regulation of toxin - antitoxin systems by ClpPC in Staphylococcus aureus 1 2
3 GlaxoSmithKline, King of Prussia, PA, 19406 8 9 *Corresponding author: 10 Department of Microbiology & Immunology, Dartmouth Medical School, Hanover, NH 11 03755 12 Phone: (603) 650-1310 Fax: (603) 650-1318 13 Email: [email protected] 14 15 16 17 Running Title: ClpPC degrades S. aureus antitoxins 18 Copyright © 2009, American Society for Microbiology and/or the Listed Authors/Insti...
متن کاملProteolytic regulation of toxin-antitoxin systems by ClpPC in Staphylococcus aureus.
Bacterial toxin-antitoxin (TA) systems typically consist of a small, labile antitoxin that inactivates a specific longer-lived toxin. In Escherichia coli, such antitoxins are proteolytically regulated by the ATP-dependent proteases Lon and ClpP. Under normal conditions, antitoxin synthesis is sufficient to replace this loss from proteolysis, and the bacterium remains protected from the toxin. H...
متن کاملToxin–antitoxin systems
Toxin-antitoxin (TA) systems are small genetic elements composed of a toxin gene and its cognate antitoxin. The toxins of all known TA systems are proteins while the antitoxins are either proteins or non-coding RNAs. Based on the molecular nature of the antitoxin and its mode of interaction with the toxin the TA modules are currently grouped into five classes. In general, the toxin is more stab...
متن کاملBacterial toxin-antitoxin systems
Toxin-antitoxin (TA) systems are composed of two elements: a toxic protein and an antitoxin which is either an RNA (type I and III) or a protein (type II). Type II systems are abundant in bacterial genomes in which they move via horizontal gene transfer. They are generally composed of two genes organized in an operon, encoding a toxin and a labile antitoxin. When carried by mobile genetic eleme...
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ژورنال
عنوان ژورنال: Toxins
سال: 2016
ISSN: 2072-6651
DOI: 10.3390/toxins8050140